Publications - last updated December, 2008

2008 | 2007 | 2006 | 2005 | 2004 | 2003 | 2002

• Auer M, Koster AJ, Ziese U, Bajaj C, Volkmann N, Wang DN, Hudspeth AJ. Three-dimensional Architecture of Hair-bundle Linkages Revealed by Electron-microscopic Tomography. J Assoc Res Otolaryngol 2008; 9 (2):215-24 PubMed
• Campbell ID. Studies of focal adhesion assembly. Biochem Soc Trans 2008; 36 (Pt 2):263-6 PubMed .
• Garduno E, Wong-Barnum M, Volkmann N, Ellisman MH. Segmentation of electron tomographic data sets using fuzzy set theory principles. J Struct Biol 2008; 162 (3):368-79 PubMed
• Gingras AR, Bate N, Goult BT, Hazelwood L, Canestrelli I, Grossmann JG, Liu H, Putz NS, Roberts GC, Volkmann N, Hanein D, Barsukov IL, Critchley DR. The structure of the C-terminal actin-binding domain of talin. Embo J 2008; 27 (2):458-69 PubMed | CMC Update article.
• Leone M, Yu EC, Liddington RC, Pasquale EB, Pellecchia M. The PTB domain of tensin: NMR solution structure and phosphoinositides binding studies. Biopolymers 2008; 89 (1):86-92 PubMed.
• Miao L, Vanderlinde O, Liu J, Grant RP, Wouterse A, Shimabukuro K, Philipse A, Stewart M, Roberts TM. The role of filament-packing dynamics in powering amoeboid cell motility. Proc Natl Acad Sci U S A 2008; 105 (14):5390-5 PubMed
• Oxley CL, Anthis NJ, Lowe ED, Vakonakis I, Campbell ID, Wegener KL. An integrin phosphorylation switch: the effect of beta3 integrin tail phosphorylation on DOK1 and talin binding. J Biol Chem 2008; 283(9):5420-6. PubMed | CMC Update article.
• Rouiller I, Xu XP, Amann KJ, Egile C, Nickell S, Nicastro D, Li R, Pollard TD, Volkmann N, Hanein D.The structural basis of actin filament branching by the Arp2/3 complex. J Cell Biol 2008;180(5):887-95. PubMed | CMC Update article.
• Wegener KL, Campbell ID. Transmembrane and cytoplasmic domains in integrin activation and protein-protein interactions. Mol Membr Biol. 2008 Aug;25(5):376-87. PubMed | CMC Update article.
• Wegener KL, Basran J, Bagshaw CR, Campbell ID, Roberts GC, Critchley DR, Barsukov IL. Structural Basis for the Interaction between the Cytoplasmic Domain of the Hyaluronate Receptor Layilin and the Talin F3 Subdomain. J Mol Biol 2008; 382(1):112-26 PubMed
• Wegener KL, Campbell ID. Transmembrane and cytoplasmic domains in integrin activation and protein-protein interactions Mol Membr Biol. 2008; 25(5):376-87. PubMed
• Ye F, Liu J, Winkler H, Taylor KA. Integrin alpha(IIb)beta(3) in a Membrane Environment Remains the Same Height after Mn(2+) Activation when Observed by Cryoelectron Tomography. J Mol Biol J Mol Biol 2008; 378 (5):976-86 PubMed | CMC Update article.

2008 | 2007 | 2006 | 2005 | 2004 | 2003 | 2002

• McCleverty CJ, Lin DC, Liddington RC. Structure of the PTB domain of tensin1 and a model for its recruitment to fibrillar adhesions.Protein Sci 2007; 16(6):1223-9 PubMed | CMC Update article.
• Lowey S, Saraswat LD, Liu H, Volkmann N, Hanein D. Evidence for an interaction between the SH3 domain and the N-terminal extension of the essential light chain in class II myosins. J Mol Biol 2007; 371 (4):902-13 PubMed.
• Luxenburg C, Geblinger D, Klein E, Anderson K, Hanein D, Geiger B, Addadi L. The architecture of the adhesive apparatus of cultured osteoclasts: from podosome formation to sealing zone assembly. PLoS ONE 2007; 2:e179 PubMed | CMC Update article.
• Hampton CM, Taylor DW, Taylor KA. Novel Structures for alpha-Actinin:F-Actin Interactions and their Implications for Actin-Membrane Attachment and Tension Sensing in the Cytoskeleton. J Mol Biol 2007; 368 (1):92-104 PubMed | CMC Update article.
• Petrich BG, Fogelstrand P, Partridge AW, Yousefi N, Ablooglu AJ, Shattil SJ, Ginsberg MH. The antithrombotic potential of selective blockade of talin-dependent integrin alpha(IIb)beta(3) (platelet GPIIb-IIIa) activation. J Clin Invest 2007; 117 (8):2250-9 PubMed.
• Petrich BG, Marchese P, Ruggeri ZM, Spiess S, Weichert RA, Ye F, Tiedt R, Skoda RC, Monkley SJ, Critchley DR, Ginsberg MH. Talin is required for integrin-mediated platelet function in hemostasis and thrombosis. J Exp Med 2007; 204 (13):3103-11 PubMed.
• Taylor DW, Kelly DF, Cheng A, Taylor KA. On the freezing and identification of lipid monolayer 2-D arrays for cryoelectron microscopy. J Struct Biol 2007; 160(3):305-12.PubMed.
• Trybus KM, Gushchin MI, Lui H, Hazelwood L, Krementsova EB, Volkmann N, Hanein D. Effect of calcium on calmodulin bound to the IQ motifs of myosin V. J Biol Chem 2007; 282 (32):23316-25. PubMed
• van der Heide P, Xu XP, Marsh BJ, Hanein D, Volkmann N. Efficient automatic noise reduction of electron tomographic reconstructions based on iterative median filtering. J Struct Biol 2007; 158 (2):196-204. PubMed | CMC Update article.
• Wegener KL, Partridge AW, Han J, Pickford AR, Liddington RC, Ginsberg MH, Campbell ID. Structural basis of integrin activation by talin. Cell 2007; 128 (1):171-82. PubMed | CMC Update article.

2008 | 2007 | 2006 | 2005 | 2004 | 2003 | 2002

• Gingras AR, Vogel KP, Steinhoff HJ, Ziegler WH, Patel B, Emsley J, Critchley DR, Roberts GC, Barsukov IL. Structural and Dynamic Characterization of a Vinculin Binding Site in the Talin Rod. Biochemistry. 2006; 45(6):1805-1817. PubMed
• Janssen ME, Kim E, Liu H, Fujimoto LM, Bobkov A, Volkmann N, Hanein D. Three-dimensional structure of vinculin bound to actin filaments. Mol Cell. 2006; 21(2):271-81. PubMed | CMC Update article.
• Kelly DF, Taylor DW, Bakolitsa C, Bobkov AA, Bankston L, Liddington RC, Taylor KA. Structure of the alpha-Actinin-Vinculin Head Domain Complex Determined by Cryo-electron Microscopy. J Mol Biol. 2006; 357(2):562-73. PubMed
• Kiema T, Lad Y, Jiang P, Oxley CL, Baldassarre M, Wegener KL, Campbell ID, Ylanne J, Calderwood DA. The Molecular Basis of Filamin Binding to Integrins and Competition with Talin. Mol Cell. 2006; 21(3):337-47. PubMed
• Patel BC, Gingras AR, Bobkov AA, Fujimoto LM, Zhang M, Liddington RC, Mazzeo D, Emsley J, Roberts GC, Barsukov IL, Critchley DR. The activity of the vinculin binding sites in talin is influenced by the stability of the helical bundles that make up the talin rod. J Biol Chem. 2006; 281(11):7458-67. PubMed
• Saunders RM, Holt MR, Jennings L, Sutton DH, Barsukov IL, Bobkov A, Liddington RC, Adamson EA, Dunn GA, Critchley DR. Role of vinculin in regulating focal adhesion turnover. Eur J Cell Bio. 2006; 85(6):487-500. PubMed
• Winkler H, Taylor KA. Accurate marker-free alignment with simultaneous geometry determination and reconstruction of tilt series in electron tomography. Ultramicroscopy. 2006; 106(3):240-54. PubMed
• Ziegler WH, Liddington RC, Critchley DR. The structure and regulation of vinculin. Trends Cell Biol 2006. 2006; 16 (9):453-60 PubMed | CMC Update article.

2008 | 2007 | 2006 | 2005 | 2004 | 2003 | 2002

• Barzik M, Kotova TI, Higgs HN, Hazelwood L, Hanein D, Gertler FB, Schafer DA. Ena/VASP proteins enhance actin polymerization in the presence of barbed end capping proteins. J Biol Chem 2005; 280 (31):28653-62 PubMed
• de Pereda JM, Wegener KL, Santelli E, Bate N, Ginsberg MH, Critchley DR, Campbell ID, Liddington RC. Structural basis for phosphatidylinositol phosphate kinase type Igamma binding to talin at focal adhesions. J Biol Chem. 2005; 280(9):8381-6. PubMed
• Egile C, Rouiller I, Xu XP, Volkmann N, Li R, Hanein D. Mechanism of filament  nucleation and branch stability revealed by the structure of the Arp2/3 complex at acting branch junctions.  PLoS Biol. 2005; 3(11):e383. PubMed
• Gingras AR, Ziegler WH, Frank R, Barsukov IL, Roberts GC, Critchley DR, Emsley J. Mapping and consensus sequence identification for multiple vinculin binding sites within the talin rod. J Biol Chem. 2005; 280(44):37217-24. PubMed
• Gupton SL, Anderson KL, Kole TP, Fischer RS, Ponti A, Hitchcock-DeGregori SE, Danuser G, Fowler VM, Wirtz D, Hanein D, Waterman-Storer CM. Cell migration without a lamellipodium: translation of actin dynamics into cell movement mediated by tropomyosin. J Cell Biol. 2005; 168(4):619-31. PubMed
• Kelly DF, Taylor KA. Identification of the beta1-integrin binding site on alpha-actinin by cryoelectron microscopy. J Struct Biol. 2005; 149(3):290-302. PubMed
• Martin AC, Xu XP, Rouiller I, Kaksonen M, Sun Y, Belmont L, Volkmann N, Hanein D, Welch M, Drubin DG. Effects of Arp2 and Arp3 nucleotide-binding pocket mutations on Arp2/3 complex function. J Cell Biol. 2005; 168(2):315-28. PubMed

2008 | 2007 | 2006 | 2005 | 2004 | 2003 | 2002

• Bakolitsa C, Cohen DM, Bankston LA, Bobkov AA, Cadwell GW, Jennings L, Critchley DR, Craig SW, Liddington RC. Structural basis for vinculin activation at sites of cell adhesion. Nature. 2004; 430(6999):583-6. PubMed
• Biyasheva A, Svitkina T, Kunda P, Baum B, Borisy G. Cascade pathway of filopodia formation downstream of SCAR. J Cell Sci. 2004; 117(Pt 6):837-48. PubMed
• Campbell ID, Ginsberg MH. The talin-tail interaction places integrin activation on FERM ground. Trends Biochem Sci 2004; 29 (8):429-35 PubMed
• Jeng RL, Goley ED, D'Alessio JA, Chaga OY, Svitkina TM, Borisy GG, Heinzen RA, Welch MD. A Rickettsia WASP-like protein activates the Arp2/3 complex and mediates actin-based motility. Cell Microbiol. 2004; 6(8):761-9. PubMed
• Lebrand C, Dent EW, Strasser GA, Lanier LM, Krause M, Svitkina TM, Borisy GG, Gertler FB.Critical role of Ena/VASP proteins for filopodia formation in neurons and in function downstream of netrin-1.Neuron. 2004; 42(1):37-49. PubMed
• Lee HS, Bellin RM, Walker DL, Patel B, Powers P, Liu H, Garcia-Alvarez B, de Pereda JM, Liddington RC, Volkmann N, Hanein D, Critchley DR, Robson RM. Characterization of an actin-binding site within the talin FERM domain. J Mol Biol. 2004; 343(3):771-84. PubMed
• Liu J, Taylor DW, Taylor KA. A 3-D reconstruction of smooth muscle alpha-actinin by CryoEm reveals two different conformations at the actin-binding region. J Mol Biol. 2004; 338(1):115-25. PubMed
• Mejillano MR, Kojima S, Applewhite DA, Gertler FB, Svitkina TM, Borisy GG. Lamellipodial versus filopodial mode of the actin nanomachinery: pivotal role of the filament barbed end. Cell 2004; 118 (3):363-73. PubMed

2008 | 2007 | 2006 | 2005 | 2004 | 2003 | 2002

• Calderwood DA, Ginsberg MH. Talin forges the links between integrins and actin. Nat Cell Biol 2003; 5 (8):694-7. PubMed
• Calderwood DA, Fujioka Y, de Pereda JM, Garcia-Alvarez B, Nakamoto T, Margolis B, McGlade CJ, Liddington RC, Ginsberg MH. Integrin beta cytoplasmic domain interactions with phosphotyrosine-binding domains: a structural prototype for diversity in integrin signaling. Proc Natl Acad Sci U S A 2003; 100 (5):2272-7. PubMed
• Garcia-Alvarez B, de Pereda JM, Calderwood DA, Ulmer TS, Critchley D, Campbell ID, Ginsberg MH, Liddington RC.Structural determinants of integrin recognition by talin. Mol Cell. 2003; 11(1):49-58. PubMed
• Liddington RC, Bankston LA, de Pereda JM."Cell Adhesion: a FERM grasp of membrane dynamics" Curr Biol. 2003; 13(3):R94-5. PubMed
• Svitkina TM, Bulanova EA, Chaga OY, Vignjevic DM, Kojima S, Vasiliev JM, Borisy GG. Mechanism of filopodia initiation by reorganization of a dendritic network. J Cell Biol 2003; 160 (3):409-21. PubMed
• Ulmer TS, Calderwood DA, Ginsberg MH, Campbell ID.Domain-specific interactions of talin with the membrane-proximal region of the integrin beta3 subunit. Biochemistry. 2003; 42(27):8307-12. PubMed
• Verkhovsky AB, Chaga OY, Schaub S, Svitkina TM, Meister JJ, Borisy GG. Orientational order of the lamellipodial actin network as demonstrated in living motile cells. Mol Biol Cell. 2003; 14(11):4667-75. PubMed
• Vignjevic D, Yarar D, Welch MD, Peloquin J, Svitkina T, Borisy GG. Formation of filopodia-like bundles in vitro from a dendritic network. J Cell Biol 2003; 160 (6):951-62 PubMed
• Volkmann N, Hanein D. Electron microscopy. Methods Biochem Anal. 2003; 44:115-33. PubMed
• Volkmann N, Hanein D. Docking of atomic models into reconstructions from electron microscopy. Methods Enzymol. 2003; 374:204-25. PubMed
• Volkmann N, Ouyang G, Trybus KM, DeRosier DJ, Lowey S, Hanein D. Myosin isoforms show unique conformations in the actin-bound state. Proc Natl Acad Sci U S A. 2003; 100(6):3227-32. PubMed

2008 | 2007 | 2006 | 2005 | 2004 | 2003 | 2002

• Bear JE, Svitkina TM, Krause M, Schafer DA, Loureiro JJ, Strasser GA, Maly IV, Chaga OY, Cooper JA, Borisy GG, Gertler FB. Antagonism between Ena/VASP proteins and actin filament capping regulates fibroblast motility. Cell. 2002; 109(4):509-21. PubMed
• Calderwood DA, Yan B, de Pereda JM, Alvarez BG, Fujioka Y, Liddington RC, Ginsberg MH. The phosphotyrosine binding (PTB)-like domain of talin activates integrins. J Biol Chem. 2002; 277:21749-21758.J Biol Chem. 2002; 277(24):21749-58. PubMed
• Hayashi I, Vuori K, Liddington RC. The focal adhesion targeting (FAT) region of focal adhesion kinase is a four-helix bundle that binds paxillin. Nat Struct Biol. 2002; 9(2):101-6. PubMed
• Liddington RC, Ginsberg MH. Integrin activation takes shape. J Cell Biol. 2002; 158(5):833-9. PubMed